Rational choice of a biomarker panel focusing on unmet scientific wants in viral kidney damage
The pipeline of biomarker translation from bench to bedside is difficult and restricted biomarkers have been adopted to routine scientific care. Ideally, biomarker analysis and improvement ought to be pushed by unmet scientific wants in well being care. To information researchers, scientific chemists and clinicians in their biomarker analysis, the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) has developed a structured questionnaire in which the scientific gaps in present scientific pathways are recognized and fascinating efficiency specs are predefined. In kidney damage, the excessive prevalence of the syndrome acute kidney damage (AKI) in the hospital setting has a important influence on morbidity, affected person survival and well being care prices, however the use of biomarkers indicating early kidney damage in day by day affected person care stays restricted.
Routinely, medical labs measure serum creatinine, which is a purposeful biomarker, insensitive for detecting early kidney harm and can not distinguish between renal and prerenal AKI. The perceived unmet scientific wants in kidney damage had been recognized via the EFLM questionnaire. Nephrologists inside our tertiary care hospital emphasised that biomarkers are wanted for (1) early analysis of in-hospital AKI after a medical insult and in critically in poor health sufferers, (2) danger stratification for kidney damage prior to a scheduled (elective) intervention, (3) kidney damage monitoring in sufferers scheduled to obtain nephrotoxic medicine and after kidney transplantation and (4) differentiation between prerenal AKI and structural kidney harm.
The biomarker search and choice technique resulted in a rational choice of an eleven-protein urinary panel for kidney damage that concentrate on these scientific wants. To assess the scientific utility of the proposed biomarker panel in kidney damage, a multiplexed LC-MS check is now in improvement for the meant translational analysis. The rugged method detection limits, calculated from measurements in greater than 60 runs, for As, Cr, and Ni are 0.23 μg L-1, 0.19 μg L-1, and 0.31 μg L-1, respectively.
Different approaches to enhance cohort identification utilizing digital well being data: X-linked hypophosphatemia for example
Electronic Health Records (EHRs) symbolize a supply of excessive worth knowledge which is commonly underutilized as a result of exploiting the knowledge contained therein requires specialised strategies unavailable to the tip person i.e. the doctor or the investigator. Here I describe 4 easy and sensible avenues that can permit the usual EHR finish person to establish affected person cohorts: the use of diagnostic codes from completely different worldwide catalogues; a search in studies from complementary assessments (e.g. radiographs or lab assessments) for any consequence of curiosity; a free textual content search; or a drug prescription search in the affected person’s digital prescription document.
This medical method is buying nice significance in the sector of uncommon ailments, and right here I display its utility with X-linked hypophosphatemia. The use of these 4 EHR questioning approaches makes discovering a cohort of sufferers of any situation or illness possible and manageable, and as soon as every case document is checked, a well-defined cohort could be assembled.
Goat IgG Isotype Control |
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GWB-B5EB81 | GenWay Biotech | 100 TESTS | Ask for price |
Goat IgG Isotype Control |
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GWB-9C0B03 | GenWay Biotech | 100 TESTS | Ask for price |
Goat IgG Isotype Control |
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GWB-7B95C3 | GenWay Biotech | 0.5 mg | Ask for price |
Goat IgG Isotype Control |
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GWB-E035B6 | GenWay Biotech | 100 TESTS | Ask for price |
Goat IgG Isotype Control |
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GWB-D15A0C | GenWay Biotech | 100 TESTS | Ask for price |
PE Goat IgG Isotype Control |
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E16FGCP006-100 | EnoGene | 100 tests | EUR 368.33 |
Description: Available in various conjugation types. |
Goat F(ab )2 IgG Isotype Control |
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GWB-4FA356 | GenWay Biotech | 100 TESTS | Ask for price |
Goat F(ab')2 IgG Isotype Control |
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abx405076-05mg | Abbexa | 0.5 mg | EUR 493.2 |
Goat F(ab )2 IgG Isotype Control |
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GWB-B1F87E | GenWay Biotech | 100 TESTS | Ask for price |
Goat F(ab )2 IgG Isotype Control |
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GWB-A21E37 | GenWay Biotech | 0.5 mg | Ask for price |
Goat F(ab )2 IgG Isotype Control |
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GWB-ECE6CB | GenWay Biotech | 100 TESTS | Ask for price |
Goat F(ab )2 IgG Isotype Control |
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GWB-827F32 | GenWay Biotech | 100 TESTS | Ask for price |
Goat F(ab )2 IgG Isotype Control |
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GWB-953EBC | GenWay Biotech | 100 TESTS | Ask for price |
Goat F(ab )2 IgG Isotype Control |
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GWB-712793 | GenWay Biotech | 100 TESTS | Ask for price |
Goat F(ab )2 IgG Isotype Control |
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GWB-CF433F | GenWay Biotech | 5 mg | Ask for price |
Goat F(ab')2 IgG Isotype Control |
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abx405076-250g | Abbexa | 250 µg | EUR 300 |
Goat IgG-PE conjugate (isotype control) |
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20011-PE | Alpha Diagnostics | 100 tests | EUR 270 |
Goat IgG-HRP conjugate (isotype control) |
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20011-HP | Alpha Diagnostics | 100 ug | EUR 196.8 |
Goat F(ab')2 IgG Isotype Control (PE) |
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abx405078-100g | Abbexa | 100 µg | EUR 437.5 |
Goat IgG-FITC conjugate (isotype control) |
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20011-F | Alpha Diagnostics | 100 ug | EUR 196.8 |
Goat F(ab')2 IgG Isotype Control (RPE) |
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abx405078-05ml | Abbexa | 0.5 ml | EUR 644.4 |
Goat F(ab')2 IgG Isotype Control (FITC) |
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abx405077-100tests | Abbexa | 100 tests | EUR 594 |
Goat F(ab')2 IgG Isotype Control (FITC) |
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abx405077-100g | Abbexa | 100 µg | EUR 387.5 |
Alexa Fluor® 647 Goat IgG Isotype Control |
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E16FGCK006-100 | EnoGene | 100 tests | EUR 563.33 |
Description: Available in various conjugation types. |
Goat IgG (fc)-HRP conjugate (isotype control) |
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20011-Fc-HP | Alpha Diagnostics | 100 ug | EUR 196.8 |
Normal Goat Polyclonal Isotype Control IgG |
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nAP-0014 | Angio Proteomie | 1mg | EUR 459 |
Goat IgG (fc)-FITC conjugate (isotype control) |
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20011-Fc-F | Alpha Diagnostics | 100 ug | EUR 196.8 |
Goat IgG (-ve control for flow cytometry) (isotype control) |
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20011-100 | Alpha Diagnostics | 100 test | EUR 123.6 |
Goat IgG (fc)-Biotin conjugate (isotype control) |
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20011-Fc-B | Alpha Diagnostics | 100 ug | EUR 196.8 |
Goat IgG, purified (serum non-immune, isotype control) |
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20011-25 | Alpha Diagnostics | 25 mg | EUR 562.8 |
Goat IgG, purified (serum non-immune, isotype control) |
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20011-5 | Alpha Diagnostics | 5 mg | EUR 343.2 |
Rat IgG-PE conjugate (isotype control) (Isotype control) |
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20005-PE | Alpha Diagnostics | 25 tests | EUR 242.4 |
Rat IgG-HRP conjugate (isotype control) (Isotype control) |
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20005-HP | Alpha Diagnostics | 100 ug | EUR 196.8 |
Rat IgG-FITC conjugate (isotype control) (Isotype control) |
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20005-F | Alpha Diagnostics | 100 ug | EUR 196.8 |
Rat IgG Isotype Control |
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31-AR15 | Fitzgerald | 10 mg | EUR 183 |
Description: Purified Rat IgG Isotype Control |
Rat IgG Isotype Control |
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GWB-37FCE4 | GenWay Biotech | 10 mg | Ask for price |
Rat IgG Isotype Control |
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GWB-4BFFB2 | GenWay Biotech | 0.5 mg | Ask for price |
Rat IgG Isotype Control |
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GWB-1E8B74 | GenWay Biotech | 0.1 mg | Ask for price |
Rat IgG Isotype Control |
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GWB-B6F703 | GenWay Biotech | 0.1 mg | Ask for price |
Dog IgG Isotype Control |
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GWB-323C1E | GenWay Biotech | 5 mg | Ask for price |
Rat IgG Isotype Control |
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GWB-7A6404 | GenWay Biotech | 0.1 mg | Ask for price |
Rat IgG Isotype Control |
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GWB-D9CFB7 | GenWay Biotech | 0.1 mg | Ask for price |
Rat IgG Isotype Control |
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GWB-76BDF3 | GenWay Biotech | 0.1 mg | Ask for price |
Rat IgG Isotype Control |
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GWB-787682 | GenWay Biotech | 0.1 mg | Ask for price |
Rat IgG Isotype Control |
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GWB-F39C54 | GenWay Biotech | 0.5 mg | Ask for price |
Rat IgG Isotype Control |
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GWB-F7A192 | GenWay Biotech | 0.5 mg | Ask for price |
Rat IgG Isotype Control |
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GWB-CFDA81 | GenWay Biotech | 0.1 mg | Ask for price |
Rat IgG Isotype Control |
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GWB-BEE47C | GenWay Biotech | 0.1 mg | Ask for price |
OOSA10406-500UG - GOAT F(ab')2 IgG NEGATIVE CONTROL Negative/Isotype Control |
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OOSA10406-500UG | Aviva Systems Biology | 0.5mg | EUR 339 |
Rat IgG-Biotin conjugate (isotype control) (Isotype control) |
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20005-B | Alpha Diagnostics | 100 ug | EUR 196.8 |
Human IgG Isotype Control |
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GWB-2CF422 | GenWay Biotech | 1.0 mg | Ask for price |
Mouse IgG Isotype Control |
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GWB-2F1CBA | GenWay Biotech | 0.1 mg | Ask for price |
Mouse IgG Isotype Control |
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GWB-552B59 | GenWay Biotech | 0.1 mg | Ask for price |
Human IgG Isotype Control |
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GWB-38F945 | GenWay Biotech | 1 ml | Ask for price |
Mouse IgG Isotype Control |
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GWB-4662CD | GenWay Biotech | 0.1 mg | Ask for price |
Mouse IgG Isotype Control |
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GWB-46ECA9 | GenWay Biotech | 0.5 mg | Ask for price |
Mouse IgG Isotype Control |
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GWB-1B0AB3 | GenWay Biotech | 0.5 mg | Ask for price |
Mouse IgG Isotype Control |
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GWB-1BE5E5 | GenWay Biotech | 10 mg | Ask for price |
Sheep IgG Isotype Control |
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GWB-1E6DA3 | GenWay Biotech | 1 mg | Ask for price |
Sheep IgG Isotype Control |
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GWB-9688FE | GenWay Biotech | 0.1 mg | Ask for price |
Mouse IgG Isotype Control |
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GWB-E00547 | GenWay Biotech | 1 ml | Ask for price |
Mouse IgG Isotype Control |
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GWB-EDB4A9 | GenWay Biotech | 0.5 mg | Ask for price |
Mouse IgG Isotype Control |
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GWB-949104 | GenWay Biotech | 0.1 mg | Ask for price |
Sheep IgG Isotype Control |
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GWB-710114 | GenWay Biotech | 5 mg | Ask for price |
Mouse IgG Isotype Control |
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GWB-75892E | GenWay Biotech | 0.1 mg | Ask for price |
Mouse IgG Isotype Control |
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GWB-D166E3 | GenWay Biotech | 0.1 mg | Ask for price |
Human IgG Isotype Control |
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GWB-BDF954 | GenWay Biotech | 1 ml | Ask for price |
Mouse IgG Isotype Control |
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GWB-BEF412 | GenWay Biotech | 0.1 mg | Ask for price |
Mouse IgG Isotype Control |
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IC002-100ul | SAB | 100ul | EUR 146.4 |
Mouse IgG Isotype Control |
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abx127121-100l | Abbexa | 100 µl | EUR 150 |
Mouse IgG Isotype Control |
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abx127121-1ml | Abbexa | 1 ml | Ask for price |
Mouse IgG Isotype Control |
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abx127121-200l | Abbexa | 200 µl | Ask for price |
Human IgG Isotype Control |
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DAGIC1333 | Creative Diagnostics | 10 mg | EUR 724.5 |
Description: Human |
Rabbit IgG Isotype Control |
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GWB-1EF918 | GenWay Biotech | 100 TESTS | Ask for price |
Rabbit IgG Isotype Control |
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GWB-12A897 | GenWay Biotech | 100 TESTS | Ask for price |
Rabbit IgG isotype control |
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AC042 | Abclonal | 100μL | EUR 292.5 |
Description: None |
Rabbit IgG Isotype Control |
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abx125003-100ul | Abbexa | 100 ul | EUR 243.6 |
Rabbit IgG Isotype Control |
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GWB-F3BC41 | GenWay Biotech | 10 mg | Ask for price |
Rabbit IgG Isotype Control |
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IC001-100ul | SAB | 100ul | EUR 146.4 |
Rabbit IgG Isotype Control |
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abx125003-100l | Abbexa | 100 µl | EUR 150 |
Rabbit IgG Isotype Control |
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abx125003-1ml | Abbexa | 1 ml | Ask for price |
Rabbit IgG Isotype Control |
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abx125003-200l | Abbexa | 200 µl | Ask for price |
Rabbit IgG Isotype Control |
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CABT-B8382 | Creative Diagnostics | 500 µg | EUR 598.5 |
Description: Rabbit |
Hamster IgG Isotype Control |
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GWB-528DB9 | GenWay Biotech | 0.1 mg | Ask for price |
Hamster IgG Isotype Control |
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GWB-419E75 | GenWay Biotech | 0.1 mg | Ask for price |
Hamster IgG Isotype Control |
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GWB-47E59E | GenWay Biotech | 0.5 mg | Ask for price |
Hamster IgG Isotype Control |
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GWB-4DBCD9 | GenWay Biotech | 0.1 mg | Ask for price |
Hamster IgG Isotype Control |
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GWB-1A8D7A | GenWay Biotech | 0.1 mg | Ask for price |
Hamster IgG Isotype Control |
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GWB-30C10C | GenWay Biotech | 0.1 mg | Ask for price |
Hamster IgG Isotype Control |
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GWB-3114BE | GenWay Biotech | 0.5 mg | Ask for price |
Hamster IgG Isotype Control |
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GWB-3413D0 | GenWay Biotech | 0.1 mg | Ask for price |
Hamster IgG Isotype Control |
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GWB-6571A8 | GenWay Biotech | 0.5 mg | Ask for price |
Hamster IgG Isotype Control |
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GWB-EE081F | GenWay Biotech | 0.5 mg | Ask for price |
Hamster IgG Isotype Control |
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GWB-C224BD | GenWay Biotech | 0.1 mg | Ask for price |
IgG Isotype Control antibody |
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10R-6524 | Fitzgerald | 50 ug | EUR 123 |
Description: Armenian Hamster monoclonal IgG Isotype Control antibody |
IgG Isotype Control antibody |
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10R-6525 | Fitzgerald | 50 ug | EUR 123 |
Description: Syrian Hamster monoclonal IgG Isotype Control antibody |
IgG Isotype Control antibody (PE) |
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61R-1337 | Fitzgerald | 200 ug | EUR 224 |
Description: Armenian Hamster monoclonal IgG Isotype Control antibody (PE) |
IgG Isotype Control antibody (PE) |
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61R-1338 | Fitzgerald | 50 ug | EUR 224 |
Description: Syrian Hamster monoclonal IgG Isotype Control antibody (PE) |
FITC Rabbit IgG - Isotype control |
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DB-1000 | DB Biotech | 100 tests | EUR 506.4 |
FITC Rabbit IgG - Isotype control |
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DB1000 | DB Biotech | 100 tests | EUR 506.4 |
Rabbit IgG Isotype Control (FITC) |
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abx227001-100g | Abbexa | 100 µg | EUR 225 |
IgG Isotype Control antibody (FITC) |
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61R-1136 | Fitzgerald | 50 ug | EUR 201 |
Description: Armenian Hamster monoclonal IgG Isotype Control antibody (FITC) |
IgG Isotype Control antibody (FITC) |
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61R-1800 | Fitzgerald | 25 ug | EUR 175 |
Description: Rabbit polyclonal IgG Isotype Control antibody (FITC) |
Hamster (Syrian) IgG Isotype Control |
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abx405032-025mg | Abbexa | 0.25 mg | EUR 460.8 |
Syrian Hamster IgG Isotype Control |
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SIGGA-100 | ImmunoStep | 100 µg | EUR 688.99 |
Syrian Hamster IgG Isotype Control |
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SIGGB-200 | ImmunoStep | 200 µg | EUR 566.69 |
Syrian Hamster IgG Isotype Control |
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SIGGF-200 | ImmunoStep | 200 µg | EUR 654.05 |
Syrian Hamster IgG Isotype Control |
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SIGGPE-100 | ImmunoStep | 100 µg | EUR 619.1 |
Syrian Hamster IgG Isotype Control |
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SIGGPP5.5-100 | ImmunoStep | 100 µg | EUR 811.3 |
Syrian Hamster IgG Isotype Control |
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SIGGPP5.5-25 | ImmunoStep | 25 µg | EUR 426.91 |
Syrian Hamster IgG Isotype Control |
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SIGGPU-500 | ImmunoStep | 500 µg | EUR 514.27 |
IgG Isotype Control antibody (biotin) |
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61R-1586 | Fitzgerald | 50 ug | EUR 198 |
Description: Armenian Hamster monoclonal IgG Isotype Control antibody (biotin) |
IgG Isotype Control antibody (biotin) |
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61R-1587 | Fitzgerald | 50 ug | EUR 198 |
Description: Syrian Hamster monoclonal IgG Isotype Control antibody (biotin) |
Purified Rabbit IgG Isotype Control |
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NRG-FlowC-01 | PHOENIX PEPTIDE | 200 μg | EUR 196.56 |
Hamster (Armenian) IgG Isotype Control |
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abx405028-025mg | Abbexa | 0.25 mg | EUR 460.8 |
Hamster (Arnenian) IgG Isotype Control |
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abx405029-05mg | Abbexa | 0.5 mg | EUR 710.4 |
Armenian Hamster IgG Isotype control |
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AIGGA-100 | ImmunoStep | 100 µg | EUR 688.99 |
Armenian Hamster IgG Isotype control |
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AIGGA-25 | ImmunoStep | 25 µg | EUR 339.55 |
Armenian Hamster IgG Isotype control |
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AIGGB-200 | ImmunoStep | 200 µg | EUR 566.69 |
Armenian Hamster IgG Isotype control |
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AIGGB-50 | ImmunoStep | 50 µg | EUR 287.14 |
Armenian Hamster IgG Isotype control |
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AIGGF-200 | ImmunoStep | 200 µg | EUR 654.05 |
Armenian Hamster IgG Isotype control |
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AIGGF-50 | ImmunoStep | 50 µg | EUR 322.08 |
Armenian Hamster IgG Isotype control |
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AIGGPE-100 | ImmunoStep | 100 µg | EUR 619.1 |
Armenian Hamster IgG Isotype control |
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AIGGPE-25 | ImmunoStep | 25 µg | EUR 304.61 |
Armenian Hamster IgG Isotype control |
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AIGGPP-100 | ImmunoStep | 100 µg | EUR 688.99 |
Armenian Hamster IgG Isotype control |
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AIGGPP-25 | ImmunoStep | 25 µg | EUR 322.08 |
Armenian Hamster IgG Isotype control |
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AIGGPP5.5-100 | ImmunoStep | 100 µg | EUR 776.35 |
Armenian Hamster IgG Isotype control |
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AIGGPP5.5-25 | ImmunoStep | 25 µg | EUR 339.55 |
Armenian Hamster IgG Isotype control |
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AIGGPU-50 | ImmunoStep | 50 µg | EUR 234.72 |
Armenian Hamster IgG Isotype control |
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AIGGPU-500 | ImmunoStep | 500 µg | EUR 514.27 |
Rat IgG, purified (Isotype control) |
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20005-5 | Alpha Diagnostics | 5 mg | EUR 343.2 |
Rat IgG purified (isotype control) |
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20005-1-200 | Alpha Diagnostics | 0.5 ml | EUR 123.6 |
Rabbit IgG Isotype control, Concentrate |
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NG910C | Innovex | 0.5 ml | EUR 295 |
Description: Rabbit IgG Isotype control, Concentrate |
Sheep IgG, purified (isotype control) |
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20006-1 | Alpha Diagnostics | 1 mg | EUR 169.2 |
PE Syrian Hamster IgG Isotype Control |
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DL22376F-20Tests | DL Develop | 20Tests | EUR 158 |
PE Syrian Hamster IgG Isotype Control |
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DL22376F-50Tests | DL Develop | 50Tests | EUR 233 |
PE Syrian Hamster IgG Isotype Control |
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DL22391F-25ug | DL Develop | 25μg | EUR 137 |
PE Syrian Hamster IgG Isotype Control |
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DL22391F-50ug | DL Develop | 50μg | EUR 182 |
Rabbit IgG Isotype Control Rabbit pAb |
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E2380763 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
IgG Isotype Control antibody (allophycocyanin) |
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61R-1768 | Fitzgerald | 100 ug | EUR 272 |
Description: Armenian Hamster monoclonal IgG Isotype Control antibody (allophycocyanin) |
IgG Isotype Control antibody (allophycocyanin) |
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61R-1769 | Fitzgerald | 50 ug | EUR 270 |
Description: Syrian Hamster monoclonal IgG Isotype Control antibody (allophycocyanin) |
Mouse IgG Isotype Control APC Conjugate |
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MAPCCON | AssayPro | 0.15 mg | EUR 213 |
Mouse IgG Isotype Control RPE Conjugate |
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MRPECON | AssayPro | 0.15 mg | EUR 213 |
FITC Syrian Hamster IgG Isotype Control |
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DL22375F-20Tests | DL Develop | 20Tests | EUR 158 |